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Velositol: Uses, Side Effects, Interactions, Dosage and Supplements

By March 6, 2019March 8th, 2019No Comments


Velositol is a patent ingredient that when used with protein is designed to accelerate and boost muscle protein synthesis (MPS), a key to enhanced muscle growth, lean body mass, and quicker muscle recovery. Velositol also enhances insulinogenic function, which increases amino acid uptake providing fuel for working muscles, so you get the most out of your workout, even after your workout.

Uses of Velositol

Velositol is an ingredient by Nutrition 21 designed to be added to protein powder to help significantly boost MPS beyond protein alone (as measured by FSR), promote leaner body composition,  doubles the power of protein on MPS vs. protein alone in a single dose and unlocks the potential of protein to enhance muscle-building activity after exercise.

Velositol, when added to protein, doubles the impact of protein on MPS versus protein alone. Velositol was designed to boost the effect of protein and exercise on MPS, positively contributing to the protein to help build muscle and improve lean body mass.Velositol on mTOR

When added to protein, Velositol’s combination of specialized, highly soluble, non-GMO amylopectin (water-soluble polysaccharide and highly branched polymer of α-glucose units found in plants), and patented chromium (appears to be directly involved in carbohydrate, fat, and protein metabolism) rapidly stimulates insulin release and increases muscle cell sensitivity to insulin. This safely increases insulin levels to enhance amino acid uptake, stimulate and boost MPS.

Clinical studies seem to support the effectiveness of Velositol. Results showed that Velositol:

  • significantly increased MPS versus protein alone (p<0.05)
  • doubled the power of protein after just a single dose*
  • was shown to create a small, non-significant increase in insulin levels
  • demonstrated no change to blood glucose levels over control

Velositol Stuides

Main Benefit: Significantly Increases Muscle Protein Synthesis vs. Protein Alone

*Velositol was studied in a randomized, double-blind, single-dose, active-controlled crossover study in which participants were given a single dose of Velositol with 6 grams of protein or 6 grams of protein alone, and completed eight sets of leg extensions up to 80 percent of their estimated maximum. Study visits and muscle biopsies were done to measure MPS over an eight hour time period. MPS was measured by calculating the fractional synthesis rate (FSR).

Interactions with Velositol

Velositol is used in protein powder supplements. Studies show that it does not particularly matter what type of protein, that Velositol has been shown to increase MPS in multiple sources of protein.

Velositol Types of Protein

Side Effects of Velositol

No serious adverse side effects have been reported. Extensive safety studies have been done with Velositol and were submitted as part of GRAS review. The ingredients in Velositol are affirmed as Generally Recognized As Safe (GRAS) or approved as a Food Additive and therefore can be used in foods (e.g., nutritional bars and beverages) and in dietary supplements.

Recommended Velositol Dosage

The recommended dosage of Velositol is 2g.

Recommended Supplements Featuring Velositol

The following products contain Velositol, and are recommended supplements for Fitness Informant:

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