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Nitrosigine: Uses, Side Effects, Interactions, Dosage and Supplements

By February 22, 2019March 7th, 2019No Comments


Nitrosigine, a patented complex of bonded arginine and silicon that has been scientifically proven to enhance performance by increasing NO (nitric oxide) levels over each ingredient tested: Arginine AKG, Agmatine Sulfate, Citrulline Malate, L-Arginine, and Citrulline. Nitrosigine is also a scientifically substantiated ingredient with 28 studies showing either efficacy or safety.

Uses of Nitrosigine

Nitrosigine is a pump enhancing ingredient from Nutrition 21 used in pre-workout and pump supplements to boost the muscle pump through increased nitric oxide production. Some other positive effects of Nitrosigine are increased energy levels and improved focus.

Nitrosigine and Muscle PumpsThe two main uses of Nitrosigine are to increase NO levels that will lead to an increased muscle pump. In a study of Nitrosigine vs. Placebo, the Nitrosigine group achieved a 2.3x larger muscle pump than the placebo group. The study consisted of 16 males. Circumference was measured prior to an intense workout and then after an intense workout. The subjects completed an intense leg extension exercise protocol to induce muscle soreness. 

The conclusion of the study showed that both primary and secondary endpoints show that daily doses of ASI prior to workout significantly increased pre-workout energy levels, increased muscle pump immediately following a workout, and decreased biomarkers of muscle damage immediately after a workout and during recovery.

A larger muscle pump is not just visually appealing, but also contributes to muscle tissue repair. The more blood flow into your muscles, the more essential nutrients are carried into the muscles to help repair damaged muscle tissue.

Nitrosigine Nitric OxideThe other main benefit of Nitrosigine in a pre-workout and pump product is that it increases NO production. An in vitro study was conducted comparing Nitrosigine to Arginine AKG, Agmatine Sulfate, Citrulline Malate, L-Arginine, and Citrulline. The results showed that Nitrosigine outperformed all of the other ingredients tested. Higher amounts of NO production leads to improved blood flow.

Nitrosigine consists of a patented complex of bonded arginine and silicon that help enhance nitric oxide levels. Arginine is an amino acid used by the body to produce nitric oxide. Nitric oxide dilates blood vessels and increases blood flow. In addition, Nitrosigine showed increased blood vessel relaxation which can help increase blood flow. In addition, blood vessel relaxation was almost 5x greater with Nitrosigine in comparison to arginine HCl.

Main Benefit: Improved Blood Flow to Elicit Pumps.

Interactions with Nitrosigine

Nitrosigine’s purpose is to increase nitric oxide levels and improve blood flow. Nitrosigine works well with other pump enhancing ingredients like theobromine, glycerol monostearate (HydroMax or GlycerPump), Citrulline, Beta Vulgaris and other ingredients that interact well with a nitric oxide enhancing ingredient like Nitrosigine.

Side Effects of Nitrosigine

No side effects are known at this time.

Recommended Nitrosigine Dosage

The recommend dosage of Nitrosigine is 750mg - 1,500mg per serving. We recommend 1,500mg here at Fitness Informant to achieve optimal results. 

Recommended Supplements Featuring Nitrosigine

The following products contain Nitrosigine, and are recommended supplements for Fitness Informant:

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