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Senactiv Shines in NutraBio’s Leg Day

By June 2, 2021December 6th, 2021No Comments
Senactiv and Leg Day

NutraBio Leg Day is a powerhouse of an intra-workout product that finds itself atop our ranking list for best intra-workout products on the market. NutraBio has a long and reputable history of formulating products to work, not based on “bro science,” but real science. This is evident by the brand’s use of nine branded ingredients in the formula. These branded ingredients include two by Nuliv Science, AstraGin, which aids in ingredient absorption, and Senactiv, which carries a multitude of benefits.


Senactiv was formally known as ActiGin. This is an ingredient that is seeing a rising popularity in formulas, especially pre and intra-workout products. The benefits of Senactiv are energy, endurance, recovery and regeneration. These four components make Senactiv the star of NutraBio’s Leg Day intra-workout supplement.

Senactiv and Energy

Senactiv® was shown in a randomized double-blind placebo-controlled crossover human clinical trial to increase the citrate synthase in muscle by 47% after a 60 min cycling exercise at 70% VO2 max.

Senactiv Citrate SynthaseThe citric acid cycle, more commonly known as the Krebs Cycle, is the sequence of reactions by which most living cells generate energy. It takes place in the mitochondria, consuming oxygen, producing carbon dioxide and water as waste products, and converting ADP to energy-rich ATP. Adenosine triphosphate (ATP) is an organic compound and hydrotrope that provides energy to drive many processes in living cells, such as muscle contraction, nerve impulse propagation, condensate dissolution, and chemical synthesis.

At 50mg in Leg Day, Senactiv is dosed correctly to help generation of ATP through the increased amount of citrate synthase during exercise.

Senactiv and Endurance

Senactiv and EnduranceYou cannot call a product Leg Day if it cannot hold up to what Leg Day should be. NutraBio knew this and incorporated Nuliv Science Senactiv due to its ability to improve endurance. Senactiv® was shown in a randomized double-blind placebo controlled crossover human clinical trial (1) to increase the time to exhaustion in high-intensity cycling (80% VO2 max) by 20%.

Nuliv Science concludes that the increase in overall endurance could stem from the abiity of Senactiv to aid in regeneration of ATP by increasing Citrate Synthase by 47%.

Other studies on Senactiv lead to the conclusion that an increase in endurance was from the reduction of muscle fatigue. During intensive exercises, Senactiv ensured a continuous supply of blood glucose into muscle.

Senactiv and Recovery

The idea behind Leg Day from NutraBio was to ensure that muscle recovery begins immediately. Muscle recovery does not need to start post-workout. It needs to start the minute of your first muscle contraction.

Senactiv is the perfect ingredient to aid in muscle recovery. Senactiv aids in muscle recovery in several ways:

  • Clearing of senescent cells
  • Increasing glycogen accumulation rate
  • Mitigating inflammatory response

Senescent cells are essentially unfit muscle cells that are detrimental to recovery. Senactiv clears them through increasing satellite muscle stem cells, glutathione, and regenerated muscle fibers.

Senactiv and GlycogenRestoration of glycogen stores occurs during the workout powered by Senactiv. It still goes to work post-workout as well ensuring glycogen is restored to aid in proper muscle recovery.

Senactiv really goes to work in Leg Day by mitigating inflammatory response in the body. Per studies, Senactiv:

  • Reduces lipid peroxidation marker TBARS by 24%
  • Reduces free radical damage to muscle
  • Reduces inflammation
  • Decreases Creatine Kinase

Senactiv and Regeneration

Senactiv RegenerationAs mentioned earlier, Senactiv clears our unfit muscle cells called senescent cells and replaces them with healthy muscle cells. Senactiv has been shown to increase the Pax-7 and Myf5 mRNA by 81% that leads to satellite cell activation, proliferation, differentiation and nucleus fusion into existing muscle tissue. Long story short, it aids in regeneration of healthy muscle cells while clearing out the unwanted ones. This aids in prolonged endurance and muscle recovery.

This is optimal in NutraBio’s Leg Day as it was formulated and designed for the athlete who cares. Cell regeneration is key to recovery and growth.

Senactiv and NutraBio’s Leg Day

NutraBio Leg Day is one of the best intra-workout formulas on the market. NutraBio didn’t skip any studies when formulating Leg Day. Partnering with a company like Nuliv Science and incorporating their Senactiv into the formula was a brilliant move. The days of an intra-workout only being an amino acid formula are over. NutraBio Leg Day, anchored by Senactiv, set the new standard for a premium intra-workout supplement.

An intra-workout, if designed properly, should aid in prolonged endurance, decreased inflammation, increased energy and increased output. Leg Day, thanks to the use of Senactiv, does exactly that.

NutraBio Leg Day

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Curious in learning more about Senactiv? Visit our Ingredient Education portal to learn about Senactiv's uses, side effects, interactions, dosage and supplements.

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